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Comparison of Monte Carlo simulated and measured performance parameters of miniPET scanner
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2007 (English)In: Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment, ISSN 0168-9002, E-ISSN 1872-9576, Vol. 571, no 02-jan, 449-452 p.Article in journal (Refereed) Published
Abstract [en]

In vivo imaging of small laboratory animals is a valuable tool in the development of new drugs. For this purpose, miniPET, an easy to scale modular small animal PET camera has been developed at our institutes. The system has four modules, which makes it possible to rotate the whole detector system around the axis of the field of view. Data collection and image reconstruction are performed using a data acquisition (DAQ) module with Ethernet communication facility and a computer cluster of commercial PCs. Performance tests were carried out to deter-mine system parameters, such as energy resolution, sensitivity and noise equivalent count rate. A modified GEANT4-based GATE Monte Carlo software package was used to simulate PET data analogous to those of the performance measurements. GATE was run on a Linux cluster of 10 processors (64 bit, Xeon with 3.0 GHz) and controlled by a SUN grid engine. The application of this special computer cluster reduced the time necessary for the simulations by an order of magnitude. The simulated energy spectra, maximum rate of true coincidences and sensitivity of the camera were in good agreement with the measured parameters.

Place, publisher, year, edition, pages
2007. Vol. 571, no 02-jan, 449-452 p.
Keyword [en]
small animal PET, performance parameters, Monte Carlo simulation
Identifiers
URN: urn:nbn:se:kth:diva-16422DOI: 10.1016/j.nima.2006.10.132ISI: 000244599100109Scopus ID: 2-s2.0-33846370085OAI: oai:DiVA.org:kth-16422DiVA: diva2:334464
Note
QC 20100525Available from: 2010-08-05 Created: 2010-08-05 Last updated: 2017-12-12Bibliographically approved

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