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Switching between on and off states of persistent activity in lateral entorhinal layer III neurons
KTH, School of Computer Science and Communication (CSC), Computational Biology, CB.ORCID iD: 0000-0003-0281-9450
2007 (English)In: Hippocampus, ISSN 1050-9631, E-ISSN 1098-1063, Vol. 17, no 4, 257-263 p.Article in journal (Refereed) Published
Abstract [en]

Persistent neural spiking maintains information during a, working memory task when a stimulus is no longer present. During I retention, this activity needs to be stable to distractors. More importantly, when retention is no longer relevant, cessation of the activity is necessary to enable processing and retention of subsequent information. Here, by means of intracellular recording with sharp microelectrode in in vitro rat brain slices, we demonstrate that single principal layer III neurons of the lateral entorhinal cortex (EC) generate persistent spiking activity with a novel ability to reliably toggle between spiking activity and a silent state. Our data indicates that in the presence of muscarmic receptor activation, persistent activity following an excitatory input may be induced and that a subsequent excitatory input can terminate this activity and cause the neuron to return to a silent state. Moreover, application of inhibitory hyperpolarizing stimuli is neither able to decrease the frequency of the persistent activity nor terminate it. The persistent activity can also be initiated and terminated by synchronized synaptic stimuli of layer II/III of the perirhinal cortex. The neuronal ability to switch On and Off persistent activity may facilitate the concurrent representation of temporally segregated information arriving in the EC and being directed toward the hippocampus.

Place, publisher, year, edition, pages
2007. Vol. 17, no 4, 257-263 p.
Keyword [en]
hippocampal formation, intrinsic properties, cholinergic modulation, post-stimulus spiking, persistent spiking activity, to-sample task, parahippocampal region, working-memory, delayed match, cortex, rat, representation, organization, connections, responses
National Category
Neurosciences Bioinformatics (Computational Biology)
Identifiers
URN: urn:nbn:se:kth:diva-16512DOI: 10.1002/hipo.20270ISI: 000245412200002Scopus ID: 2-s2.0-34247516389OAI: oai:DiVA.org:kth-16512DiVA: diva2:334554
Note
QC 20100525Available from: 2010-08-05 Created: 2010-08-05 Last updated: 2017-12-12Bibliographically approved

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Fransén, Erik

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