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Exploring GABAergic and dopaminergic effects in a minimal model of a medium spiny projection neuron
KTH, School of Computer Science and Communication (CSC), Computational Biology, CB.ORCID iD: 0000-0002-0550-0739
2007 (English)In: Neurocomputing, ISSN 0925-2312, Vol. 70, no 12-okt, 1615-1618 p.Article in journal (Refereed) Published
Abstract [en]

Striatum is the input stage of the basal ganglia, a collection of nuclei in the midbrain. The basal ganglia are involved in cognitive and motor behaviour, including reward-dependent learning. The reward system in the brain is heavily linked to the dopaminergic system, and many striatal neurons react in a reward-dependent manner. This study explores a minimal model of a striatal medium spiny (MS) projection neuron displaying dopamine-induced bistability. MS neurons mostly fluctuate between two states, a hyperpolarised down-state and a depolarised up-state. MS neurons are only active in the up-state and therefore spiking requires the transition from the down-state. For high dopamine levels in the model, the appearance of a bifurcation results in more distinct state transitions. GABAergic input from local fast-spiking interneurons to MS neurons results in a small depolarisation, but far from causing a transition to the up-state by itself. We investigate if a GABAergic PSP could facilitate the transition to the up-state elicited by glutamatergic input. The model predicts that GABAergic input to MS neurons might facilitate and speed up the transition to the up-state. The prerequisite for this is that the GABAergic enhancement starts slightly before the glutamatergic increase which causes the up-state transition.

Place, publisher, year, edition, pages
2007. Vol. 70, no 12-okt, 1615-1618 p.
Keyword [en]
striatum, medium spiny projection neuron, dopamine, GABA, nucleus-accumbens, interneurons, inhibition, modulation, striatum
URN: urn:nbn:se:kth:diva-16687ISI: 000247215300006ScopusID: 2-s2.0-34247513404OAI: diva2:334730
QC 20100525Available from: 2010-08-05 Created: 2010-08-05 Last updated: 2012-01-08Bibliographically approved

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Hellgren Kotaleski, Jeanette
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