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Neural response profile design: Reducing epileptogenic activity by modifying neuron responses to synchronized input using novel potassium channels obtained by parameter search optimization
KTH, School of Computer Science and Communication (CSC), Computational Biology, CB.ORCID iD: 0000-0003-0281-9450
2007 (English)In: Neurocomputing, ISSN 0925-2312, Vol. 70, no 10-12, 1630-1634 p.Article in journal (Refereed) Published
Abstract [en]

Neurons obtain their dynamical electrical characteristics by a set of ion channels. These properties may not only affect the function of the neuron and the local network it forms part of, but it may also eventually affect behavior. We were interested to study whether epileptogenic activity could be reduced by adding an ion channel. In this work, we used computational search techniques to optimize ion channel properties for the goal of modifying neural response characteristics. Our results show that this type of parameter search is possible and reasonably efficient. Successful searches were generated using the direct method PRAXIS, and by systematic searches in low-dimensional sub-spaces. We also report on unsuccessful searches using a simplex-type method, a gradient-based method, and attempts to reduce goal function evaluation time. Importantly, using this search strategy, our study has shown that it is possible to change a neuron's characteristics selectively with regard to response to degree of synchronicity in synaptic input.

Place, publisher, year, edition, pages
AMSTERDAM: ELSEVIER SCIENCE , 2007. Vol. 70, no 10-12, 1630-1634 p.
Keyword [en]
optimization, computational search, biophysical modeling, potassium channel, synchronization, epileptogenesis, hippocampal pyramidal neurons, gamma oscillations, k+ conductance, dendrites, models
National Category
Neurosciences Bioinformatics (Computational Biology)
URN: urn:nbn:se:kth:diva-16688DOI: 10.1016/j.neucom.2006.10.046ISI: 000247215300009ScopusID: 2-s2.0-34247464173OAI: diva2:334731
QC 20100525 QC 20111214Available from: 2010-08-05 Created: 2010-08-05 Last updated: 2011-12-14Bibliographically approved

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Fransén, Erik
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