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Towards, a theory of tiered testing
KTH, School of Architecture and the Built Environment (ABE), Philosophy.
KTH, School of Architecture and the Built Environment (ABE), Philosophy.
2007 (English)In: Regulatory toxicology and pharmacology, ISSN 0273-2300, E-ISSN 1096-0295, Vol. 48, no 1, 35-44 p.Article in journal (Refereed) Published
Abstract [en]

Tiered testing is an essential part of any resource-efficient strategy for the toxicity testing of a large number of chemicals, which is required for instance in the risk management of general (industrial) chemicals, In spite of this, no general theory seems to be available for the combination of single tests into efficient tiered testing systems. A first outline of such a theory is developed. It is argued that chemical, toxicological, and decision-theoretical knowledge should be combined in the construction of such a theory. A decision-theoretical approach for the optimization of test systems is introduced. It is based on expected utility maximization with simplified assumptions covering factual and value-related information that is usually missing in the development of test systems.

Place, publisher, year, edition, pages
2007. Vol. 48, no 1, 35-44 p.
Keyword [en]
tiered testing, test strategies, expected utility, validity, reliability, sensitivity, cost-efficiency, REACH, toxicity data, statistical-analysis, risk assessment, human hazard, chemicals, extrapolation, strategies, prediction, carcinogenicity, potency
URN: urn:nbn:se:kth:diva-16727DOI: 10.1016/j.yrtph.2006.12.003ISI: 000247549700005ScopusID: 2-s2.0-34249065905OAI: diva2:334770
QC 20100525Available from: 2010-08-05 Created: 2010-08-05Bibliographically approved

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