Degradation profile of poly(epsilon-caprolactone) - the influence of macroscopic and macromolecular biomaterial design
2007 (English)In: Journal of macromolecular science. Pure and applied chemistry (Print), ISSN 1060-1325, E-ISSN 1520-5738, Vol. 44, no 7-9, 1041-1046 p.Article in journal (Refereed) Published
Macroscopic and macromolecular material design and their influence on hydrolysis mechanism of poly(epsilon-caprolactone) (PCL) was evaluated. Homogoenous discs of linear PCL, porous scaffolds of linear PCL and crosslinked PCL networks were subjected to hydrolytic degradation for up to 364 days in 37 degrees C and pH 7.4 phosphate buffer solution. After different hydrolysis times, mass loss and changes in molecular weight and thermal properties were determined in parallel to extraction and analysis of the formed degradation products. Size exclusion chromatography (SEC), differential scanning calorimetry (DSC) and gas chromatography-mass spectrometry (GC-MS) were used for the analyses. The results clearly demonstrated different degradation profiles and susceptibilities towards hydrolysis depending on the macroscopic and macromolecular biomaterial design.
Place, publisher, year, edition, pages
2007. Vol. 44, no 7-9, 1041-1046 p.
degradation, hydrolysis, poly(epsilon-caprolactone), macromolecular design, film-blown poly(epsilon-caprolactone), in-vitro degradation, epsilon-caprolactone, aliphatic polyesters, scaffolds, 1, 5-dioxepan-2-one, polycaprolactone, biodegradation, copolymers, products
Polymer Chemistry Polymer Technologies
IdentifiersURN: urn:nbn:se:kth:diva-16756DOI: 10.1080/10601320701424487ISI: 000247724400050ScopusID: 2-s2.0-34250875108OAI: oai:DiVA.org:kth-16756DiVA: diva2:334799
QC 201005252010-08-052010-08-052016-05-30Bibliographically approved