Change search
ReferencesLink to record
Permanent link

Direct link
Ventilation-perfusion relationships in pulmonary arterial hypertension: Effect of intravenous and inhaled prostacyclin treatment
Department of Clinical Physiology, Karolinska University Hospital, Huddinge.
Show others and affiliations
2007 (English)In: Respiratory Physiology & Neurobiology, ISSN 1569-9048, E-ISSN 1878-1519, Vol. 158, no 1, 59-69 p.Article in journal (Refereed) Published
Abstract [en]

In seven patients with idiopathic or secondary pulmonary arterial hypertension (PAH), ventilation-perfusion (V-A/Q) relationships were measured during a right heart catheterization using the multiple inert-gas elimination technique before and during intravenous infusion with epoprostenol (EPO), and following 5 months of 20 mu g inhaled iloprost taken three times daily (ILO). Pre-treatment pulmonary vascular resistance (PVR) was 9.3 +/- 5.0 mmHg/l/min and the dispersion of perfusion and ventilation for V-A/Q-ratios was increased. EPO reduced PVR by 20%, and increased cardiac output, shunt, and mixed venous oxygenation (Sv(O2)) The arterial oxygen tension (Pa-O2) remained unchanged. Basal central haemodynamics did not change after 5 months of ILO. Fifteen minutes after ILO, PVR decreased by 20%, and the shunt, Sv(O2), and Pa-O2 remained unaltered. Conclusions: In secondary PAH with normal lung volumes, significant V-A/Q mismatching occurred. The PVR was reduced to a similar degree during EPO and after ILO, but only EPO increased the shunt and Sv(O2). EPO and ILO did not significantly affect the Pa-O2.

Place, publisher, year, edition, pages
2007. Vol. 158, no 1, 59-69 p.
Keyword [en]
V-A/Q ratios, multiple inert-gas elimination technique, shunt, mixed venous oxygenation, pulmonary arterial hypertension, epoprostenol, inhaled iloprost, hypoxaemia, gas-exchange, nitric-oxide, continuous distributions, cardiac-output, disease, exercise, iloprost, therapy, inequality, mechanisms
National Category
Medical and Health Sciences
URN: urn:nbn:se:kth:diva-16809DOI: 10.1016/j.resp.2007.03.003ISI: 000248158100010OAI: diva2:334852
QC 20100525Available from: 2010-08-05 Created: 2010-08-05 Last updated: 2012-03-23Bibliographically approved

Open Access in DiVA

No full text

Other links

Publisher's full text

Search in DiVA

By author/editor
Brodin, Lars-Åke
In the same journal
Respiratory Physiology & Neurobiology
Medical and Health Sciences

Search outside of DiVA

GoogleGoogle Scholar
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 28 hits
ReferencesLink to record
Permanent link

Direct link