In vitro formation of nanocrystalline carbonate apatite - A structural and morphological analogue of atherosclerotic plaques
2007 (English)In: European Journal of Inorganic Chemistry, ISSN 1434-1948, E-ISSN 1099-0682, no 26, 4123-4127 p.Article in journal (Refereed) Published
The in vitro formation of carbonate apatite in solutions with ion concentrations comparable to those in human serum was studied. The composition and morphology of the resulting apatite precipitate displayed a hierarchical assembly of elongated plate-shaped nanocrystals of carbonate apatite analogous to previously characterized bioapatites formed in The main conclusion is that so-called bioapatites may form in vitro and that precipitation inhibitors most likely are essential for the prevention of spontaneous calcification at normal human serum ion concentrations.
Place, publisher, year, edition, pages
2007. no 26, 4123-4127 p.
carbonate apatite, crystallization, calcification, nanocrystalline, calcium, calcification, dialysis, serum, hydroxyapatite, morphogenesis, phosphate, arteries, protein, growth, mice
IdentifiersURN: urn:nbn:se:kth:diva-16978DOI: 10.1002/ejic.200700654ISI: 000249767700003ScopusID: 2-s2.0-34748836558OAI: oai:DiVA.org:kth-16978DiVA: diva2:335021
QC 20100525. Tidigare titel: "Spontaneous in vitro Calcification in Physiological Salt and Buffer Solution with Normal Human Serum Ionized Calcium and Inorganic Phosphate Concentrations".2010-08-052010-08-052010-12-20Bibliographically approved