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Stress-modulated collagen fiber remodeling in a human carotid bifurcation
KTH, School of Engineering Sciences (SCI), Solid Mechanics (Dept.).
2007 (English)In: Journal of Theoretical Biology, ISSN 0022-5193, E-ISSN 1095-8541, Vol. 248, no 3, 460-470 p.Article in journal (Refereed) Published
Abstract [en]

This work concerns with the implementation of a new stress-driven remodeling model for simulating the overall structure and mechanical behavior of a human carotid bifurcation. By means of an iterative finite element based procedure collagen fiber direction and maximal principal stresses are computed. We find that the predicted fibers' architecture at the cylindrical branches and at the apex of the bifurcation correlates well with histological observations. Some insights about the mechanical response of the sinus bulb and the bifurcation apex are revealed and discussed. The results are compared with other, isotropic and orthotropic, models available in the literature.

Place, publisher, year, edition, pages
2007. Vol. 248, no 3, 460-470 p.
Keyword [en]
soft tissues, carotid artery bifurcation, remodeling, hyperelasticity, FE analysis, arterial-wall stress, human brain arteries, reinforced composites, computational aspects, structural model, tissue, atherosclerosis, growth, flow, deformations
URN: urn:nbn:se:kth:diva-17004DOI: 10.1016/j.jtbi.2007.05.037ISI: 000249948200005ScopusID: 2-s2.0-34548439879OAI: diva2:335047
QC 20100525Available from: 2010-08-05 Created: 2010-08-05Bibliographically approved

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Gasser, T. Christian
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