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Duplication of FGF3, FGF4, FGF19 and ORAOV1 causes hair ridge and predisposition to dermoid sinus in Ridgeback dogs
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2007 (English)In: Nature Genetics, ISSN 1061-4036, Vol. 39, no 11, 1318-1320 p.Article in journal (Refereed) Published
Abstract [en]

The dorsal hair ridge in Rhodesian and Thai Ridgeback dogs is caused by a dominant mutation that also predisposes to the congenital developmental disorder dermoid sinus. Here we show that the causative mutation is a 133-kb duplication involving three fibroblast growth factor (FGF) genes. FGFs play a crucial role in development, suggesting that the ridge and dermoid sinus are caused by dysregulation of one or more of the three FGF genes during development.

Place, publisher, year, edition, pages
2007. Vol. 39, no 11, 1318-1320 p.
Keyword [en]
expression, cells, gene
URN: urn:nbn:se:kth:diva-17080ISI: 000250575900015ScopusID: 2-s2.0-35349010252OAI: diva2:335123
QC 20100525Available from: 2010-08-05 Created: 2010-08-05Bibliographically approved

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Savolainen, Peter
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Gene Technology
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