Biochemical alterations in the trapezius muscle of patients with chronic whiplash associated disorders (WAD) - A microdialysis study
2008 (English)In: European Journal of Pain, ISSN 1090-3801, E-ISSN 1532-2149, Vol. 12, no 1, 82-93 p.Article in journal (Refereed) Published
The mechanisms behind the development of chronic trapezius myalgia in patients with whiplash associated disorders (WAD) appear to involve both peripheral and central components, but the specific contribution of alterations in muscle is not clear. Female patients with WAD and involvement of trapezius (N = 22) and female controls (N = 20; CON) were studied during an experiment compromised of rest (baseline), 20 min repetitive low.-force exercise and 120 min recovery. Their interstitial concentrations of serotonin (5-HT), glutamate, lactate, pyruvate, potassium, interleukin-6 (IL-6), and blood flow were determined in the trapezius muscle using a microdialysis technique. Pressure pain thresholds (PPT) over trapezius and tibialis anterior muscles were also assessed. In WAD, we found signs of generalized hypersensitivity according to PPT. The WAD group had significantly higher interstitial [IL-6] and [5-HT] in the trapezius than the CON. [Pyruvate] was overall significantly lower in WAD, and with lactate it showed another time-pattern throughout the test. In the multivariate regression analysis of pain intensity [5-HT] was the strongest regressor and positively correlated with pain intensity in WAD. In addition, blood flow, [pyruvate], and [potassium] influenced the pain intensity in a complex time dependent way. These findings may indicate that peripheral nociceptive processes are activated in WAD with generalized hypersensitivity for pressure and they are not identical with those reported in chronic work-related trapezius myalgia, which could indicate different pain mechanisms.
Place, publisher, year, edition, pages
2008. Vol. 12, no 1, 82-93 p.
lactate, pyruvate, serotonin, glutamate, muscle pain, sensitization, whiplash, zygapophysial joint pain, human skeletal-muscle, blood-flow, sensory, hypersensitivity, cervical-spine, neck pain, exercise, tissue, fibromyalgia, cytokines
IdentifiersURN: urn:nbn:se:kth:diva-17258DOI: 10.1016/j.ejpain.2007.03.009ISI: 000251934200011OAI: oai:DiVA.org:kth-17258DiVA: diva2:335301
QC 201005252010-08-052010-08-05Bibliographically approved