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Comment on "Regularizing capacity of metabolic networks"
KTH, School of Computer Science and Communication (CSC), Computational Biology, CB.
2008 (English)Article in journal (Refereed) Published
Abstract [en]

In a recent paper, Marr, Muller-Linow, and Hutt [Phys. Rev. E 75, 041917 (2007)] investigate an artificial dynamic system on metabolic networks. They find a less complex time evolution of this dynamic system in real networks, compared to networks of null models. The authors argue that this suggests that metabolic network structure is a major factor behind the stability of biochemical steady states. We reanalyze the same kind of data using a dynamic system modeling actual reaction kinetics. The conclusions about stability, from our analysis, are inconsistent with those of Marr We argue that this issue calls for a more detailed type of modeling.

Place, publisher, year, edition, pages
2008. Vol. 77, no 2
URN: urn:nbn:se:kth:diva-17356DOI: 10.1103/PhysRevE.77.023901ISI: 000253763700110ScopusID: 2-s2.0-38949184272OAI: diva2:335400
QC 20100525Available from: 2010-08-05 Created: 2010-08-05Bibliographically approved

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Holme, Petter
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