Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Transcriptional profiling of melanocytes from patients with vitiligo vulgaris
Show others and affiliations
2008 (English)In: Pigment Cell & Melanoma Research, ISSN 1755-1471, Vol. 21, no 2, 162-171 p.Article in journal (Refereed) Published
Abstract [en]

Vitiligo is a complex, polygenic disorder characterized by patchy loss of skin pigmentation due to abnormal melanocyte function. Both genetic and environmental etiological factors have been proposed for vitiligo and lack of molecular markers renders difficulties to predict development and progression of the disease. Identification of dysregulated genes has the potential to unravel biological pathways involved in vitiligo pathogenesis, facilitating discovery of potential biomarkers and novel therapeutic approaches. In this study, we characterized the transcriptional profile of melanocytes from vitiligo patients. Oligonucleotide microarrays containing similar to 16 000 unique genes were used to analyse mRNA expression in melanocytes from vitiligo patients and age-matched healthy controls. In total, 859 genes were identified as differentially expressed. A substantial number of these genes were involved in (i) melanocyte development, (ii) intracellular processing and trafficking of tyrosinase gene family proteins, (iii) packing and transportation of melanosomes, (iv) cell adhesion and (v) antigen processing and presentation. In conclusion, our results show a significantly different transcription profile in melanocytes from vitiligo patients compared with controls. Several genes of potential importance for the pathogenesis and development of vitiligo were identified. Our data indicate that autoimmunity involving melanocytes may be a secondary event in vitiligo patients caused by abnormal melanocyte function.

Place, publisher, year, edition, pages
2008. Vol. 21, no 2, 162-171 p.
Keyword [en]
vitiligo, melanocytes, microarray, transcription profiling, tyrosinase, gene family, melanosome transport, cell adhesion, antigen presentation, cdna microarray data, generalized vitiligo, autoimmune-diseases, cultured melanocytes, oxidative stress, binding proteins, myosin-va, expression, skin, trafficking
Identifiers
URN: urn:nbn:se:kth:diva-17456DOI: 10.1111/j.1755-148X.2007.00429.xISI: 000255061700010Scopus ID: 2-s2.0-42249100012OAI: oai:DiVA.org:kth-17456DiVA: diva2:335500
Note
QC 20100525Available from: 2010-08-05 Created: 2010-08-05 Last updated: 2010-08-10Bibliographically approved

Open Access in DiVA

No full text

Other links

Publisher's full textScopus

Search in DiVA

By author/editor
Lundeberg, JoakimNilsson, Peter
By organisation
Gene TechnologyProteomicsAlbanova VinnExcellence Center for Protein Technology, ProNova

Search outside of DiVA

GoogleGoogle Scholar

doi
urn-nbn

Altmetric score

doi
urn-nbn
Total: 51 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf