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Assessment of left ventricular volumes using simplified 3-D echocardiography and computed tomography - a phantom and clinical study
KTH, School of Technology and Health (STH), Medical Engineering, Medical Imaging.ORCID iD: 0000-0001-9419-910X
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2008 (English)In: Cardiovascular Ultrasound, ISSN 1476-7120, Vol. 6Article in journal (Refereed) Published
Abstract [en]

Objectives: To compare the accuracy of simplified 3-dimensional (3-D) echocardiography vs. multi-slice computed tomography (MSCT) software for the quantification of left ventricular (LV) volumes. Design: Three-D echocardiography (3-planes approach) and MSCT-CardIQ software were calibrated by measuring known volumes of 10 phantoms designed to closely mimic blood-endocardium interface. Subsequently, LV volumes were measured with both the methods in 9 patients referred routinely for coronary angiography and the agreement between the measurements was evaluated. Results: Simplified 3D-echocardiography provided higher degree of agreement between the measured and true phantom volumes (mean difference 0 +/- 1 ml, variation range + 4 to -4 ml) than MSCT software (mean difference 6 +/- 5 ml; variation range + 22 to -10 ml). The agreement between LV measurements in the patients was considerably poorer, with significantly larger volumes produced by MSCT (mean difference - 23 +/- 40 ml, variation between + 93 and -138 ml). Conclusion: Simplified 3-D echocardiography provides more accurate assessment of phantom volumes than MSCT-CardIQ software. The discrepancy between the results of LV measurements with the two methods is even greater and does not warrant their interchangeable diagnostic use.

Place, publisher, year, edition, pages
2008. Vol. 6
Keyword [en]
cardiac magnetic-resonance, 3-dimensional echocardiography, 2-dimensional echocardiography, ejection fraction, size, cineventriculography, quantification, transducer, spect
National Category
Medical Laboratory and Measurements Technologies Medical Equipment Engineering
URN: urn:nbn:se:kth:diva-17613DOI: 10.1186/1476-7120-6-26ISI: 000256849500001ScopusID: 2-s2.0-44949255615OAI: diva2:335657

QC 20100525

Available from: 2010-08-05 Created: 2010-08-05 Last updated: 2014-12-01Bibliographically approved
In thesis
1. Evaluation of Errors and Limitations in Ultrasound Imaging Systems
Open this publication in new window or tab >>Evaluation of Errors and Limitations in Ultrasound Imaging Systems
2011 (English)Doctoral thesis, comprehensive summary (Other academic)
Abstract [en]

There are binding regulations requiring safety and efficacy aspects of medical devices. The requirements ask for documentation that the devices are safe and effective for their intended use, i.e. if a device has a measuring function it must be correct. In addition to this there are demands for quality systems describing development, manufacturing, labelling, and manufacturing of a device. The requirements are established to guarantee that non-defective medical devices are used in the routine clinical practice. The fast rates in which the imaging modalities have evolved during the last decades have resulted in numerous new diagnostic tools, such as velocity and deformation imaging in ultrasound imaging. However, it seems as if the development of evaluation methods and test routines has not been able to keep up the same pace. Two of the studies in this thesis, Study I and IV, showed that computed tomography-based and ultrasound based volume measurements can yield very disparate measurements, and that tissue Doppler imaging-based ultrasound measurements can be unreliable.

Furthermore, the new ultrasound modalities impose higher demands on the ultrasound transducers. Transducers are known to be fragile, but defective transducers were less of a problem earlier when the ultrasound systems to a lesser extent were used for measurements. The two other studies, Study II and III, showed that serious transducer errors are very common, and that annual testing of the transducers is not sufficient to guarantee an error free function.

The studies in the thesis indicate that the system with Notified Bodies, in accordance with the EU’s Medical Device Directive, checking the function and manufacturing of medical devices does not work entirely satisfactory. They also show that the evaluation of new methods have led to the undesirable situation, where new measuring tools, such as volume rendering from imaging systems, and tissue Doppler-based velocity and deformation imaging in echocardiography are available for clinicians without proven knowledge about their accuracy.

Place, publisher, year, edition, pages
Stockholm: KTH Royal Institute of Technology, 2011. x, 74 p.
Trita-STH : report, ISSN 1653-3836 ; 2011:3
National Category
Medical Laboratory and Measurements Technologies
urn:nbn:se:kth:diva-34177 (URN)978-91-7501-026-7 (ISBN)
Public defence
2011-06-10, Sal 3-221, Alfred Nobels Allé 10, Flemingsberg, 13:00 (Swedish)
QC 20110527Available from: 2011-05-27 Created: 2011-05-27 Last updated: 2011-05-30Bibliographically approved

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Mårtensson, MattiasBrodin, Lars-Åke
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