Fingerprinting the degradation product patterns of different polyester-ether networks by electrospray ionization mass spectrometry
2008 (English)In: Journal of Polymer Science Part A: Polymer Chemistry, ISSN 0887-624X, E-ISSN 1099-0518, Vol. 46, no 13, 4617-4629 p.Article in journal (Refereed) Published
Fingerprinting of the degradation product patterns by electrospray ionization mass spectrometry (ESI-MS) was evaluated as a tool to monitor the degree of degradation in polyester-ether networks. Four different crosslinked caprolactone (CL) and/ or 1,5-dioxepan-2-one (DXO) networks were subjected to hydrolytic degradation in aqueous solution at 37 degrees C for up to 147 days. After predetermined time periods, the water-soluble degradation products were analyzed by ESI-MS and tandem ESI-MS. In addition, changes in pH, mass loss, and copolymer composition were determined. In the case of more slowly hydrolyzed CL-rich (co)polymers, CL and/or DXO oligomers terminated by hydroxyl and carboxyl end groups were predominantly formed as degradation products. However, on prolonged hydrolysis oligomers with attached crosslinking agent dominated the degradation product patterns of more easily hydrolyzed DXO-rich (co)polymers. It was shown that in the recorded mass spectra the variation of intensities in the series of ions corresponding to DXO and CL/DXO oligomers with or without attached crosslinking agent could be utilized to monitor the extent of hydrolytic degradation in the polyester matrix and the disruption of the network structure.
Place, publisher, year, edition, pages
2008. Vol. 46, no 13, 4617-4629 p.
biocompatibility, crosslinking, degradation, mass spectrometry, polyesters, molecular-weight products, in-vitro degradation, epsilon-caprolactone, matrix changes, 1, 5-dioxepan-2-one, polymers, poly(epsilon-caprolactone), polyethylene, polylactide, delivery
Polymer Chemistry Polymer Technologies
IdentifiersURN: urn:nbn:se:kth:diva-17642DOI: 10.1002/pola.22796ISI: 000257153500033ScopusID: 2-s2.0-46349108984OAI: oai:DiVA.org:kth-17642DiVA: diva2:335686
QC 201005252010-08-052010-08-052016-05-30Bibliographically approved