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Impact of the self-assembly of multilayer polyelectrolyte functionalized gold nanorods and its application to biosensing
KTH, School of Electrical Engineering (EES), Electromagnetic Engineering.ORCID iD: 0000-0002-3401-1125
2008 (English)In: Nanotechnology, ISSN 0957-4484, E-ISSN 1361-6528, Vol. 19, no 35Article in journal (Refereed) Published
Abstract [en]

Multilayered polyelectrolyte functionalized gold nanorods (GNRs) are reported for the conjugation of and sensitive detection of bio-molecules. Multilayered polyelectrolyte functionalized GNRs can significantly improve the biocompatibility of cetyltrimethylammonium bromide ( CTAB) coated GNRs in a bio-environment and can diminish the toxicity induced by CTAB. Biotin, bovine serum albumin (BSA)-biotin and streptavidin are conjugated to polyelectrolyte functionalized GNRs, and the conjugates can serve as a platform for many biotin-streptavidin-based biological applications. Through the robust self-assembly effect of GNRs, biotin-conjugated GNRs are also utilized as a very sensitive probe for the detection of a small amount of streptavidin.

Place, publisher, year, edition, pages
2008. Vol. 19, no 35
Keyword [en]
enhanced raman-scattering, nanoparticles, cancer, immobilization, absorption, therapy, spectra
URN: urn:nbn:se:kth:diva-17718DOI: 10.1088/0957-4484/19/35/355501ISI: 000257843900017OAI: diva2:335763
QC 20100525Available from: 2010-08-05 Created: 2010-08-05 Last updated: 2013-11-19Bibliographically approved

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