Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Protein release from galactoglucomannan hydrogels: Influence of substitutions and enzymatic hydrolysis by beta-mannanase
KTH, School of Chemical Science and Engineering (CHE), Fibre and Polymer Technology.ORCID iD: 0000-0002-1631-1781
KTH, School of Chemical Science and Engineering (CHE), Fibre and Polymer Technology.
Show others and affiliations
2008 (English)In: Biomacromolecules, ISSN 1525-7797, E-ISSN 1526-4602, Vol. 9, no 8, 2104-2110 p.Article in journal (Refereed) Published
Abstract [en]

O-Acetyl-galactoglucomannan (AcGGM) is the major soft-wood hemicellulose. Structurally modified AcGGM and hydrogels of AcGGM were prepared. The degree of substitution (DS) of AcGGM was modified enzymatically with beta-galactosidase, and chemically with an acrylate derivative, 2-hydroxyethylmethacrylate (HEMA). The hydrolysis of AcGGM with beta-mannanase was shown to increase with decreasing DS. AcGGM hydrogels were prepared from chemically modified AcGGM with varying DS of HEMA. Bovine serum albumin (BSA) was encapsulated in hydrogels. A spontaneous burst release of BSA was decreased with increased DS of HEMA. The addition of beta-mannanase significantly enhanced the BSA release from hydrogels with a DS of 0.36, reaching a maximum of 95% released BSA after eight hours compared to 60% without enzyme. Thus, both the pendant group composition and the enzyme action are valuable tools in the tailoring of hydrogel release profiles of potential interest for intestine drug delivery.

Place, publisher, year, edition, pages
2008. Vol. 9, no 8, 2104-2110 p.
Keyword [en]
hemicellulose-based hydrogels, aspergillus-niger, biodegradable, polymers, degrading enzymes, substrate-binding, renewable sources, purification, polysaccharides, galactomannans, galactosidases
Identifiers
URN: urn:nbn:se:kth:diva-17758DOI: 10.1021/bm701399mISI: 000258400200003Scopus ID: 2-s2.0-52649167335OAI: oai:DiVA.org:kth-17758DiVA: diva2:335803
Note
QC 20100525Available from: 2010-08-05 Created: 2010-08-05 Last updated: 2017-12-12Bibliographically approved

Open Access in DiVA

No full text

Other links

Publisher's full textScopus

Authority records BETA

Edlund, Ulrica

Search in DiVA

By author/editor
Edlund, UlricaAlbertsson, Ann-Christine
By organisation
Fibre and Polymer Technology
In the same journal
Biomacromolecules

Search outside of DiVA

GoogleGoogle Scholar

doi
urn-nbn

Altmetric score

doi
urn-nbn
Total: 43 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf