Resorbable Scaffolds from Three Different Techniques: Electrospun Fabrics, Salt-Leaching Porous Films, and Smooth Flat Surfaces
2008 (English)In: Macromolecular Bioscience, ISSN 1616-5187, E-ISSN 1616-5195, Vol. 8, no 10, 951-959 p.Article in journal (Refereed) Published
Nanofibrous scaffolds of poly[(L-lactide)-co-(1,5-dioxepan-2-one)] generated by electrospinning have been compared with porous films obtained by solvent cast/salt leaching and homogeneous films. A comparison between the fibrous materials and the homogeneous solvent-cast films revelead that the surface of the nanofibers was more hydrophobic and that the nanofibers were degraded more rapidly in the presence of proteinase. It was obvious that the strain-to-break was reduced by the nanofiber formation, it decreased from 370% to 130% independent of fiber diameter. These values were however considerably higher than the strain-to-break of the solvent-cast/salt leaching scaffold. In addition, the nanofibrous material accelerated the adhesion and growth of the mesenchymal stem cell compared to the smooth material.
Place, publisher, year, edition, pages
2008. Vol. 8, no 10, 951-959 p.
cell proliferation, degradation, electrospinning, structure/property, relations, tissue engineering, mechanical-properties, nanofiber scaffolds, fibers, cell, regeneration, membrane, adhesion
IdentifiersURN: urn:nbn:se:kth:diva-17925DOI: 10.1002/mabi.200700328ISI: 000260474100007ScopusID: 2-s2.0-60549094659OAI: oai:DiVA.org:kth-17925DiVA: diva2:335970
QC 201005252010-08-052010-08-05Bibliographically approved