Change search
ReferencesLink to record
Permanent link

Direct link
Keeping the blood flowing-plasminogen activator genes and feeding behavior in vampire bats
KTH, School of Biotechnology (BIO), Gene Technology.
Show others and affiliations
2009 (English)In: Die Naturwissenschaften, ISSN 0028-1042, E-ISSN 1432-1904, Vol. 96, no 1, 39-47 p.Article in journal (Refereed) Published
Abstract [en]

The blood feeding vampire bats emerged from New World leaf-nosed bats that fed on fruit and insects. Plasminogen activator, a serine protease that regulates blood coagulation, is known to be expressed in the saliva of Desmodus rotundus (common vampire bat) and is thought to be a key enzyme for the emergence of blood feeding in vampire bats. To better understand the evolution of this biological function, we studied the plasminogen activator (PA) genes from all vampire bat species in light of their feeding transition to bird and subsequently mammalian blood. We include the rare species Diphylla ecaudata and Diaemus youngi, where plasminogen activator had not previously been studied and demonstrate that PA gene duplication observed in Desmodus is not essential to the vampire phenotype, but relates to the emergence of predominant mammalian blood feeding in this species. Plasminogen activator has evolved through gene duplication, domain loss, and sequence evolution leading to change in fibrin-specificity and susceptibility to plasminogen activator inhibitor-1. Before undertaking this study, only the four plasminogen activator isoforms from Desmodus were known. The evolution of vampire bat plasminogen activators can now be linked phylogenetically to the transition in feeding behavior among vampire bat species from bird to mammalian blood.

Place, publisher, year, edition, pages
2009. Vol. 96, no 1, 39-47 p.
Keyword [en]
Species adaptation, Positive selection, Domain evolution, Gene, duplication, Ecological niche, detecting positive selection, likelihood ratio tests, desmodus-rotundus, maximum-likelihood, tissue, evolution, fibrin, determinants, inhibitor-1, phylogenies
URN: urn:nbn:se:kth:diva-18057DOI: 10.1007/s00114-008-0446-0ISI: 000261791000004ScopusID: 2-s2.0-57849116386OAI: diva2:336103
QC 20100525Available from: 2010-08-05 Created: 2010-08-05 Last updated: 2011-01-24Bibliographically approved

Open Access in DiVA

No full text

Other links

Publisher's full textScopus

Search in DiVA

By author/editor
Savolainen, Peter
By organisation
Gene Technology
In the same journal
Die Naturwissenschaften

Search outside of DiVA

GoogleGoogle Scholar
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 20 hits
ReferencesLink to record
Permanent link

Direct link