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Generations of sequencing technologies
KTH, School of Biotechnology (BIO), Gene Technology.
KTH, School of Biotechnology (BIO), Gene Technology.
KTH, School of Biotechnology (BIO), Gene Technology.
2009 (English)In: Genomics, ISSN 0888-7543, E-ISSN 1089-8646, Vol. 93, no 2, 105-111 p.Article, review/survey (Refereed) Published
Abstract [en]

Advancements in the field of DNA sequencing are changing the scientific horizon and promising an era of personalized medicine for elevated human health. Although platforms are improving at the rate of Moore's Law, thereby reducing the sequencing costs by a factor of two or three each year, we find ourselves at a point in history where individual genomes are starting to appear but where the cost is still too high for routine sequencing of whole genomes. These needs will be met by miniaturized and parallelized platforms that allow a lower sample and template consumption thereby increasing speed and reducing costs. Current massively parallel, state-of-the-art systems are providing significantly improved throughput over Sanger systems and future single-molecule approaches will continue the exponential improvements in the field.

Place, publisher, year, edition, pages
2009. Vol. 93, no 2, 105-111 p.
Keyword [en]
DNA sequencing, Next generation, nucleotide reversible terminators, ocean sampling expedition, human, genome, dna, gene, dideoxynucleotides, diversity, arrays
URN: urn:nbn:se:kth:diva-18165DOI: 10.1016/j.ygeno.2008.10.003ISI: 000263227600001ScopusID: 2-s2.0-58249138817OAI: diva2:336211
QC 20100525Available from: 2010-08-05 Created: 2010-08-05 Last updated: 2011-01-13Bibliographically approved

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