Asymmetric Lewis Acid Mediated 1,2 -Rearrangement of Proline-Derived Ammonium Ylides
2009 (English)In: Organic Letters, ISSN 1523-7060, E-ISSN 1523-7052, Vol. 11, no 4, 919-921 p.Article in journal (Refereed) Published
The first example of asymmetric Lewis acid mediated [1,2]-rearrangement of N-benzylic proline amides to form quaternary proline derivatives is reported. The presented reaction is shown to proceed with remarkable high C-N-C chirality transfer. Various quaternary proline derivatives have been prepared in good to excellent yields and high enantiomeric purity.
Place, publisher, year, edition, pages
2009. Vol. 11, no 4, 919-921 p.
IdentifiersURN: urn:nbn:se:kth:diva-18170DOI: 10.1021/ol8028803ISI: 000263299000034ScopusID: 2-s2.0-62749167066OAI: oai:DiVA.org:kth-18170DiVA: diva2:336216
QC 201005252010-08-052010-08-052011-01-17Bibliographically approved