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Bifunctional Dendrimers: From Robust Synthesis and Accelerated One-Pot Postfunctionalization Strategy to Potential Applications
KTH, School of Chemical Science and Engineering (CHE), Fibre and Polymer Technology.
KTH, School of Chemical Science and Engineering (CHE), Fibre and Polymer Technology.
KTH, School of Technology and Health (STH), Neuronic Engineering (Closed 20130701).
KTH, School of Chemical Science and Engineering (CHE), Fibre and Polymer Technology.
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2009 (English)In: Angewandte Chemie International Edition, ISSN 1433-7851, E-ISSN 1521-3773, Vol. 48, no 12, 2126-2130 p.Article in journal (Refereed) Published
Place, publisher, year, edition, pages
2009. Vol. 48, no 12, 2126-2130 p.
Keyword [en]
click chemistry, dendrimers, gels, nanoparticles, synthetic methods, phosphorus-containing dendrimers, dendritic macromolecules, click, chemistry, rapid synthesis, terminal alkynes, polymers, architectures, molecules, growth, azides
National Category
Polymer Technologies
URN: urn:nbn:se:kth:diva-18270DOI: 10.1002/anie.200804987ISI: 000264411800015ScopusID: 2-s2.0-61949478182OAI: diva2:336316

QC 20100525

Available from: 2010-08-05 Created: 2010-08-05 Last updated: 2016-06-22Bibliographically approved
In thesis
1. Multifunctional Dendritic Scaffolds: Synthesis, Characterization and Potential applications
Open this publication in new window or tab >>Multifunctional Dendritic Scaffolds: Synthesis, Characterization and Potential applications
2013 (English)Doctoral thesis, comprehensive summary (Other academic)
Abstract [en]

The development of materials for advanced applications requires innovative macromolecules with well-defined structures and the inherent ability to be tailored in a straightforward manner. Dendrimers, being a subgroup of the dendritic polymer family, possess properties which fulfill such demands. They have a highly branched architecture with a high number of functional groups and are one of the most well-defined types of macromolecules ever synthesized. However, despite their well-defined nature and high functional density, traditional dendrimers commonly lack diverse chemical functionalities. Therefore, this thesis focuses on the synthesis of more complex dendritic materials to extend their tailoring capacity by introduction of dualfunctionalities for multipurpose actions. It covers the synthesis of dualfunctional dendrimers, dendritic modification of linear poly(ethylene glycol) polymers and cellulose surfaces, and the synthesis of linear dendritic hybrids. The building blocks enabling this synthesis, AB2C monomers, were also developed during this work. The orthogonal nature between click groups (azide, alkyne and alkene) and hydroxyl groups have efficiently been utilized for postfunctionalization by robust click chemistry and traditional esterification reactions. Furthermore, linear dendritic hybrids were synthesized, merging the properties of linear and dendritic macromolecules. The dendritic frameworks were tailored towards the production of bone fracture adhesives, novel biofunctional dendritic hydrogels, biosensors and micellar drug delivery vehicles.

Abstract [sv]

Utveckling av material för avancerade applikationer kräver innovativa makromolekyler med väldefinierade strukturer och som kan skräddarsys på ett enkelt sätt. Dendrimerer är en undergrupp av dendritiska polymerer vars egenskaper uppfyller dessa krav. De har en mycket förgrenad arkitektur med många funktionella grupper och är en av de mest väldefinierade befintliga syntetiska makromolekylerna. Trots dess väldefinierade karaktär och höga funktionalitet saknar ofta traditionella dendrimerer multipla kemiska funktionaliteter. Denna avhandling fokuserar därför på syntesen av mer komplexa dendritiska material för att förbättra deras kapacitet att skräddarsys, detta görs genom att introducera fler funktionaliteter som kan utnyttjas för multipla ändamål . Avhandlingen redogör för syntesen av difunktionella dendrimerer, dendritiska modifikationer av polyetylenglykol och cellulosaytor samt syntes av traditionella dendritiska hybrider. Byggstenarna som möjliggör syntesen, AB2C monomerer, framställdes också under detta arbete. Den ortogonala karaktären mellan klick grupper (azid, alkyn och alkene) och hydroxylgrupper har utnyttjats effektivt för funktionaliseringar genom användande av robust ”Click”-kemi och traditionella esterifikationsreaktioner. Vidare tillverkades de linjära dendritiska hybrider för att kombinera egenskaperna hos både linjära och traditionella dendritiska polymerer i en och samma makromolekyl. Samtliga dendritiska strukturer skräddarsyddes för applikationer så som benlimmer, biofunktionella dendritiska hydrogeler, biosensorer och läkemedels-bärande miceller.

Place, publisher, year, edition, pages
Stockholm: KTH Royal Institute of Technology, 2013. 87 p.
Trita-CHE-Report, ISSN 1654-1081 ; 2013:32
Dendrimer, AB2C monomer, Click chemistry, CuAAC, thiol-ene coupling chemistry, TEC, linear dendritic hybrids, micelle, hydrogel, bone adhesive
National Category
Polymer Chemistry
urn:nbn:se:kth:diva-127429 (URN)978-91-7501-817-1 (ISBN)
Public defence
2013-09-20, Sal F3, Lindstedtsvägen 26, KTH, Stockholm, 10:00 (English)

QC 20130830

Available from: 2013-08-30 Created: 2013-08-29 Last updated: 2013-08-30Bibliographically approved

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Antoni, PerHed, YvonneNordberg, AxelNyström, Danielvon Holst, HansHult, AndersMalkoch, Michael
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