Colloidal mesoporous silica nanoparticles with protoporphyrin IX encapsulated for photodynamic therapy
2009 (English)In: Journal of Biomedical Optics, ISSN 1083-3668, Vol. 14, no 1Article in journal (Refereed) Published
Protoporphyrin IX (PpIX)-encapsulated mesoporous silica nanoparticles were synthesized, characterized, and utilized for photodynamic therapy (PDT) of cancer. Silica encapsulation is relatively transparent for activated light and can protect the PpIX against denaturation induced by the extreme bioenvironment. The mesoporous silica can also ensure that the encapsulated PpIX can be well-contacted with oxygen, stimulated, and released. PpIX-encapsulated colloidal mesoporous silica nanoparticles were uptaken by tumor cells in vitro, and the effect of photon-induced toxicity was demonstrated after comparison with some control experiments. The surface of PpIX-encapsulated silica nanoparticles can be grafted with appropriate functionalized groups and conjugated with certain biomolecules for specific targeting.
Place, publisher, year, edition, pages
2009. Vol. 14, no 1
PpIX-encapsulated silica nanoparticles, fluorescence imaging, uptake, photodynamic therapy, polymeric micelles, photosensitizers, delivery, excitation, tumor
IdentifiersURN: urn:nbn:se:kth:diva-18288DOI: 10.1117/1.3083427ISI: 000264551900017ScopusID: 2-s2.0-65349114808OAI: oai:DiVA.org:kth-18288DiVA: diva2:336334
QC 201005252010-08-052010-08-052013-11-19Bibliographically approved