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Formation of carbonated apatite particles from a supersaturated inorganic blood serum model
KTH, School of Chemical Science and Engineering (CHE), Chemistry, Inorganic Chemistry.
KTH, School of Chemical Science and Engineering (CHE), Chemistry, Inorganic Chemistry.
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2009 (English)In: Journal of materials science. Materials in medicine, ISSN 0957-4530, E-ISSN 1573-4838, Vol. 20, no 8, 1677-1687 p.Article in journal (Refereed) Published
Abstract [en]

Pathological calcification is common among for instance dialysis patients, and this causes an increase in mortality risk. An elevated serum phosphate concentration among those patients strongly correlates to this increase. In this work investigations of the conditions, composition, crystallinity and morphology of in vitro calcification are performed and related to results from in vivo studies. The study was performed under conditions mimicking physiological ones, i.e. a pH around 7.40, a temperature of 37A degrees C, an ionic strength of 150 mM and ion concentrations close to those in human serum including the effects of elevated phosphate concentrations. The course of precipitation involves an initial precipitate that subsequently re-dissolves to give another precipitate, in accordance with the well-known Ostwald ripening theory. The final bulk precipitate consists of a macroscopically amorphous carbonated apatite. The amorphous apatite is formed from assemblies of spherical particles in the mu m range, in turn composed of nano-crystalline needles of about 10 x 100 nm. Even the initially formed precipitate, as well as a small amount of precipitate that occurs on the liquid surface, consist of a carbonated calcium phosphate. The in vitro observed carbonated apatite bears strong resemblance to in vivo cardiovascular calcification known from literature.

Place, publisher, year, edition, pages
2009. Vol. 20, no 8, 1677-1687 p.
National Category
Inorganic Chemistry
Identifiers
URN: urn:nbn:se:kth:diva-18615DOI: 10.1007/s10856-009-3735-zISI: 000268103300012Scopus ID: 2-s2.0-68149124109OAI: oai:DiVA.org:kth-18615DiVA: diva2:336662
Note
QC 20100525Available from: 2010-08-05 Created: 2010-08-05 Last updated: 2011-01-19Bibliographically approved
In thesis
1. Calcium phosphate precipitation in blood serum model solutions
Open this publication in new window or tab >>Calcium phosphate precipitation in blood serum model solutions
2005 (English)Licentiate thesis, comprehensive summary (Other scientific)
Place, publisher, year, edition, pages
Stockholm: KTH, 2005. xiv, 45 p.
Series
Trita-OOK, ISSN 0348-825X ; 1082
National Category
Inorganic Chemistry
Identifiers
urn:nbn:se:kth:diva-576 (URN)91-7178-217-6 (ISBN)
Presentation
2005-12-15, sal K2, KTH, Teknikringen 28, Stockholm, 14:00
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Note
QC 20101220Available from: 2005-12-28 Created: 2005-12-28 Last updated: 2010-12-20Bibliographically approved

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