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The observation of nano-crystalline calcium phosphate precipitate in a simple supersaturated inorganic blood serum model - composition and morphology
KTH, School of Chemical Science and Engineering (CHE), Chemistry, Inorganic Chemistry.
KTH, School of Chemical Science and Engineering (CHE), Chemistry, Inorganic Chemistry.
2009 (English)In: Journal of Applied Biomaterials and Biomechanics, ISSN 1722-6899, Vol. 7, no 1, 13-22 p.Article in journal (Refereed) Published
Abstract [en]

Aim. Calcium phosphate deposition in blood vessels is correlated to increased mortality risk. In this study, the formation of solid calcium phosphate in an in vitro solution mimicking the inorganic part of blood serum was studied. Methods. The precipitates formed were analyzed using several experimental techniques, including infrared spectroscopy, Raman spectroscopy, X-ray energy dispersive spectroscopy, chemical analysis of combustion gases, thermogravimetric analysis, as well as transmission electron microscopy and scanning electron microscopy. Results. The results indicate a microscopically amorphous but nano-crystalline material with an overall apatite structure. A plausible stoichiometry was determined to Ca-5(PO4)(3)(HCO3)center dot 4H(2)O with an estimated solubility constant of 6.10(-39) (mol/L)(9). Bicarbonate in the water solution was shown to be essential for the precipitation, giving implications for in vitro studies. Conclusions. The calcium phosphate formed in this study shows many similarities to pathological calcium phosphates regarding composition, morphology and crystallinity.

Place, publisher, year, edition, pages
2009. Vol. 7, no 1, 13-22 p.
Keyword [en]
Apatite, Carbonated apatite, Mineralization, Nano-crystalline
National Category
Inorganic Chemistry
Identifiers
URN: urn:nbn:se:kth:diva-18697ISI: 000269103400002PubMedID: 20740434Scopus ID: 2-s2.0-68149130919OAI: oai:DiVA.org:kth-18697DiVA: diva2:336744
Note
QC 20100525Available from: 2010-08-05 Created: 2010-08-05 Last updated: 2010-12-20Bibliographically approved
In thesis
1. Calcium phosphate precipitation in blood serum model solutions
Open this publication in new window or tab >>Calcium phosphate precipitation in blood serum model solutions
2005 (English)Licentiate thesis, comprehensive summary (Other scientific)
Place, publisher, year, edition, pages
Stockholm: KTH, 2005. xiv, 45 p.
Series
Trita-OOK, ISSN 0348-825X ; 1082
National Category
Inorganic Chemistry
Identifiers
urn:nbn:se:kth:diva-576 (URN)91-7178-217-6 (ISBN)
Presentation
2005-12-15, sal K2, KTH, Teknikringen 28, Stockholm, 14:00
Opponent
Supervisors
Note
QC 20101220Available from: 2005-12-28 Created: 2005-12-28 Last updated: 2010-12-20Bibliographically approved

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