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Selective IgA deficiency in early life: Association to infections and allergic diseases during childhood
KTH, School of Biotechnology (BIO), Proteomics.ORCID iD: 0000-0003-1363-5796
KTH, School of Biotechnology (BIO), Proteomics.
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2009 (English)In: Clinical Immunology, ISSN 1521-6616, E-ISSN 1521-7035, Vol. 133, no 1, 78-85 p.Article in journal (Refereed) Published
Abstract [en]

Selective IgA deficiency in early life is quite common in Caucasian populations, but it is unclear whether it increases the risk of infections and allergic diseases during childhood. Serum IgA levels were measured in 2423 children at 4 years of age in a Swedish population based birth cohort (BAMSE). Parental questionnaires were repeatedly sent out during the child's first 8 years of life, collecting information about infections and allergic diseases. 14 children (1:173) were found to be IgA deficient at 4 years of age. These children had an increased risk of pseudocroup at year 1 (p<0.01) and food hypersensitivity at year 4 (p<0.05) as compared to IgA sufficient children. No increased risk was observed in the partial IgA deficiency group. The findings suggest that selective IgA deficiency may increase the risk of parentally reported pseudocroup and food hypersensitivity during early childhood.

Place, publisher, year, edition, pages
2009. Vol. 133, no 1, 78-85 p.
Keyword [en]
Selective IgA deficiency, Allergic diseases, Infections, Children, BAMSE, Serum microarrays, immunoglobulin-a deficiency, food hypersensitivity, celiac-disease, 4-year-old children, antibody deficiency, pediatric-patients, c3, deficiency, blood-donors, serum, prevalence
Identifiers
URN: urn:nbn:se:kth:diva-18806DOI: 10.1016/j.clim.2009.05.014ISI: 000270292400009OAI: oai:DiVA.org:kth-18806DiVA: diva2:336853
Note
QC 20100525Available from: 2010-08-05 Created: 2010-08-05 Last updated: 2017-12-12Bibliographically approved

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