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Engineering Nanomaterial Surfaces for Biomedical Applications
KTH, School of Chemical Science and Engineering (CHE), Chemistry, Organic Chemistry.
KTH, School of Chemical Science and Engineering (CHE), Chemistry.
2009 (English)In: Experimental biology and medicine (Maywood, N.J.: Print), ISSN 1535-3702, E-ISSN 1535-3699, Vol. 234, no 10, 1128-1139 p.Article in journal (Refereed) Published
Abstract [en]

Nanomaterials, possessing unique physical and chemical properties, have attracted much interest and generated wide varieties of applications. Recent investigations of functionalized nanomaterials have expanded into the biological area, providing a versatile platform in biomedical applications such as biomolecular sensing, biological imaging, drug delivery and disease therapy. Bio-functions and bio-compatibility of nanomaterials are realized by introducing synthetic ligands or natural biomolecules onto nanomaterials, and combining ligand-receptor biological interactions with intrinsic nanomaterial properties. Common strategies of engineering nanomaterial surfaces involve physisorption or chemisorption of desired ligands. We developed a phollochemically initiated surface coupling chemistry, bringing versatility and simplicity to nanomaterial functionalization. The method was applied to attach underivatized carbohydrates efficiently on gold and iron oxide nanoparticles, and the resulting glyconanoparticles were successfully used as a sensitive biosensing system probing specific interactions between carbohydrates and proteins as well as bacteria. Exp Biol Med 234:1128-1139, 2009

Place, publisher, year, edition, pages
2009. Vol. 234, no 10, 1128-1139 p.
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Chemical Sciences
URN: urn:nbn:se:kth:diva-18818DOI: 10.3181/0904-mr-134ISI: 000270347800003ScopusID: 2-s2.0-70349679109OAI: diva2:336865

QC 20100525

Available from: 2010-08-05 Created: 2010-08-05 Last updated: 2016-04-18Bibliographically approved

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