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Modelling and sensitivity analysis of the reactions involving receptor, G-protein and effector in vertebrate olfactory receptor neurons
KTH, School of Computer Science and Communication (CSC), Computational Biology, CB.
KTH, School of Computer Science and Communication (CSC), Computational Biology, CB.
KTH, School of Computer Science and Communication (CSC), Computational Biology, CB.
KTH, School of Computer Science and Communication (CSC), Computational Biology, CB.ORCID iD: 0000-0002-0550-0739
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2009 (English)In: Journal of Computational Neuroscience, ISSN 0929-5313, E-ISSN 1573-6873, Vol. 27, no 3, 471-491 p.Article in journal (Refereed) Published
Abstract [en]

A biochemical model of the receptor, G-protein and effector (RGE) interactions during transduction in the cilia of vertebrate olfactory receptor neurons (ORNs) was developed and calibrated to experimental recordings of cAMP levels and the receptor current (RC). The model describes the steps from odorant binding to activation of the effector enzyme which catalyzes the conversion of ATP to cAMP, and shows how odorant stimulation is amplified and delayed by the RGE transduction cascade. A time-dependent sensitivity analysis was performed on the model. The model output-the cAMP production rate-is particularly sensitive to a few, dominant parameters. During odorant stimulation it depends mainly on the initial density of G-proteins and the catalytic constant for cAMP production.

Place, publisher, year, edition, pages
2009. Vol. 27, no 3, 471-491 p.
Keyword [en]
Olfaction, Receptor neuron, Biochemical model, Sensitivity analysis, Receptor potential, Signal transduction, nucleotide-gated conductance, cyclic-amp, computational model, adenylyl-cyclase, transduction, cilia, cells, adaptation, odorants, calcium
Identifiers
URN: urn:nbn:se:kth:diva-18891DOI: 10.1007/s10827-009-0162-6ISI: 000271105700010Scopus ID: 2-s2.0-70350569929OAI: oai:DiVA.org:kth-18891DiVA: diva2:336938
Note
QC 20100525Available from: 2010-08-05 Created: 2010-08-05 Last updated: 2017-12-12Bibliographically approved

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Hellgren Kotaleski, Jeanette

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Halnes, GeirUlfhielm, ErikLjunggren, Emma EklöfHellgren Kotaleski, Jeanette
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