Simple cellular and network control principles govern complex patterns of motor behavior
2009 (English)In: Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, E-ISSN 1091-6490, Vol. 106, no 47, 20027-20032 p.Article in journal (Refereed) Published
The vertebrate central nervous system is organized in modules that independently execute sophisticated tasks. Such modules are flexibly controlled and operate with a considerable degree of autonomy. One example is locomotion generated by spinal central pattern generator networks (CPGs) that shape the detailed motor output. The level of activity is controlled from brainstem locomotor command centers, which in turn, are under the control of the basal ganglia. By using a biophysically detailed, full-scale computational model of the lamprey CPG (10,000 neurons) and its brainstem/forebrain control, we demonstrate general control principles that can adapt the network to different demands. Forward or backward locomotion and steering can be flexibly controlled by local synaptic effects limited to only the very rostral part of the network. Variability in response properties within each neuronal population is an essential feature and assures a constant phase delay along the cord for different locomotor speeds.
Place, publisher, year, edition, pages
2009. Vol. 106, no 47, 20027-20032 p.
basal ganglia, brainstem, computational model, lamprey, spinal CPG, spinal locomotor network, intersegmental coordination, fictive, locomotion, coupled oscillators, rhythm generation, lamprey, mechanisms, neurons, cord, motoneurons
IdentifiersURN: urn:nbn:se:kth:diva-18996DOI: 10.1073/pnas.0906722106ISI: 000272180900053ScopusID: 2-s2.0-73949102883OAI: oai:DiVA.org:kth-18996DiVA: diva2:337043
QC 201005252010-08-052010-08-052012-01-08Bibliographically approved