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Simple cellular and network control principles govern complex patterns of motor behavior
KTH, School of Computer Science and Communication (CSC), Computational Biology, CB.
KTH, School of Computer Science and Communication (CSC), Computational Biology, CB.
KTH, School of Computer Science and Communication (CSC), Computational Biology, CB.ORCID iD: 0000-0002-2358-7815
KTH, School of Computer Science and Communication (CSC), Computational Biology, CB.ORCID iD: 0000-0002-0550-0739
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2009 (English)In: Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, E-ISSN 1091-6490, Vol. 106, no 47, 20027-20032 p.Article in journal (Refereed) Published
Abstract [en]

The vertebrate central nervous system is organized in modules that independently execute sophisticated tasks. Such modules are flexibly controlled and operate with a considerable degree of autonomy. One example is locomotion generated by spinal central pattern generator networks (CPGs) that shape the detailed motor output. The level of activity is controlled from brainstem locomotor command centers, which in turn, are under the control of the basal ganglia. By using a biophysically detailed, full-scale computational model of the lamprey CPG (10,000 neurons) and its brainstem/forebrain control, we demonstrate general control principles that can adapt the network to different demands. Forward or backward locomotion and steering can be flexibly controlled by local synaptic effects limited to only the very rostral part of the network. Variability in response properties within each neuronal population is an essential feature and assures a constant phase delay along the cord for different locomotor speeds.

Place, publisher, year, edition, pages
2009. Vol. 106, no 47, 20027-20032 p.
Keyword [en]
basal ganglia, brainstem, computational model, lamprey, spinal CPG, spinal locomotor network, intersegmental coordination, fictive, locomotion, coupled oscillators, rhythm generation, lamprey, mechanisms, neurons, cord, motoneurons
Identifiers
URN: urn:nbn:se:kth:diva-18996DOI: 10.1073/pnas.0906722106ISI: 000272180900053Scopus ID: 2-s2.0-73949102883OAI: oai:DiVA.org:kth-18996DiVA: diva2:337043
Note
QC 20100525Available from: 2010-08-05 Created: 2010-08-05 Last updated: 2017-12-12Bibliographically approved

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Hellgren Kotaleski, Jeanette

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