The plasticity of the mammalian transcriptome
2010 (English)In: Genomics, ISSN 0888-7543, E-ISSN 1089-8646, Vol. 95, no 1, 1-6 p.Article, review/survey (Refereed) Published
The dogmatic view of RNA as a mere necessity in the transfer of information between DNA and proteins has during recent years come into question. Novel approaches and new technology has revealed an unprecedented level of inherent complexity in the mammalian transcriptome. Here, the majority of nucleotides are expressed, in sharp contrast to the similar to 1.2% of the human genome harboring protein coding information. Also, >50% of genomic loci contain antisense and interleaved transcription, a conservative estimate since non-coding RNA is highly regulated between tissues and developmental stages, which has only been investigated to a limited extent. Subsequent focus on RNA with no coding potential has revealed numerous species with novel functions, and deep sequencing studies imply that many remain to be discovered. This review gives an overview of the plasticity and dynamics of the mammalian transcriptome and the prevailing interpretation of its effect on the complexity of species.
Place, publisher, year, edition, pages
2010. Vol. 95, no 1, 1-6 p.
RNA, Transcriptome plasticity, Regulatory RNA, Noncoding RNA, Pervasive, transcription, long noncoding rnas, gene-expression, messenger-rnas, human genome, drosophila-melanogaster, antisense transcription, caenorhabditis-elegans, transposable elements, dna demethylation, eukaryotic cells
IdentifiersURN: urn:nbn:se:kth:diva-19126DOI: 10.1016/j.ygeno.2009.08.010ISI: 000273838300001OAI: oai:DiVA.org:kth-19126DiVA: diva2:337173
FunderKnut and Alice Wallenberg Foundation
QC 201005252010-08-052010-08-052011-01-27Bibliographically approved