Change search
ReferencesLink to record
Permanent link

Direct link
The plasticity of the mammalian transcriptome
KTH, School of Biotechnology (BIO), Gene Technology.
KTH, School of Biotechnology (BIO), Gene Technology.
2010 (English)In: Genomics, ISSN 0888-7543, E-ISSN 1089-8646, Vol. 95, no 1, 1-6 p.Article, review/survey (Refereed) Published
Abstract [en]

The dogmatic view of RNA as a mere necessity in the transfer of information between DNA and proteins has during recent years come into question. Novel approaches and new technology has revealed an unprecedented level of inherent complexity in the mammalian transcriptome. Here, the majority of nucleotides are expressed, in sharp contrast to the similar to 1.2% of the human genome harboring protein coding information. Also, >50% of genomic loci contain antisense and interleaved transcription, a conservative estimate since non-coding RNA is highly regulated between tissues and developmental stages, which has only been investigated to a limited extent. Subsequent focus on RNA with no coding potential has revealed numerous species with novel functions, and deep sequencing studies imply that many remain to be discovered. This review gives an overview of the plasticity and dynamics of the mammalian transcriptome and the prevailing interpretation of its effect on the complexity of species.

Place, publisher, year, edition, pages
2010. Vol. 95, no 1, 1-6 p.
Keyword [en]
RNA, Transcriptome plasticity, Regulatory RNA, Noncoding RNA, Pervasive, transcription, long noncoding rnas, gene-expression, messenger-rnas, human genome, drosophila-melanogaster, antisense transcription, caenorhabditis-elegans, transposable elements, dna demethylation, eukaryotic cells
National Category
Industrial Biotechnology
URN: urn:nbn:se:kth:diva-19126DOI: 10.1016/j.ygeno.2009.08.010ISI: 000273838300001OAI: diva2:337173
Knut and Alice Wallenberg Foundation
QC 20100525Available from: 2010-08-05 Created: 2010-08-05 Last updated: 2011-01-27Bibliographically approved

Open Access in DiVA

No full text

Other links

Publisher's full text

Search in DiVA

By author/editor
Lindberg, JohanLundeberg, Joakim
By organisation
Gene Technology
In the same journal
Industrial Biotechnology

Search outside of DiVA

GoogleGoogle Scholar
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 27 hits
ReferencesLink to record
Permanent link

Direct link