Aqueous Synthesis and Fluorescence-Imaging Application of CdTe/ZnSe Core/Shell Quantum Dots with High Stability and Low Cytotoxicity
2010 (English)In: Journal of Nanoscience and Nanotechnology, ISSN 1533-4880, Vol. 10, no 3, 1741-1746 p.Article in journal (Refereed) Published
CdTe/ZnSe core/shell quantum dots were directly synthesized in an aqueous condition by heating a mixed solution of ZnCl2, NaHSe and CdTe QDs in the presence of mercaptosuccinic acid as a stabilizer. By controlling the size and composition, the CdTe/ZnSe QDs with emission wavelength ranging from 540 to 630 nm, high quantum yield (44%) and narrow full width at half maximum (FWHM) could be obtained. Characterization results with HRTEM, XRD and EDX have shown that the synthesized CdTe/ZnSe ON have good monodispersity and a nice crystal structure, and exhibited better stability and less cytotoxicity as compared with CdTe QDs. Furthermore, luminescent QD-IgG bioprobes were produced to detect the breast cancer marker Her2 on the surface of fixed MCF-7 cancer cells for their optical imaging.
Place, publisher, year, edition, pages
2010. Vol. 10, no 3, 1741-1746 p.
Optical Imaging, Quantum Dots, Aqueous Synthesis, Cytotoxicity, Stability, Fluorescence, Core-Shell Structure, cdte nanocrystals, in-vivo, room-temperature, size series, photoluminescence, photostability, nanoparticles, therapy, vitro
Chemical Sciences Materials Engineering Condensed Matter Physics
IdentifiersURN: urn:nbn:se:kth:diva-19153DOI: 10.1166/jnn.2010.2049ISI: 000273984800037ScopusID: 2-s2.0-77950955285OAI: oai:DiVA.org:kth-19153DiVA: diva2:337200
QC 201005252010-08-052010-08-052013-11-19Bibliographically approved