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On modelling and analysis of healthy and pathological human mitral valves: Two case studies
KTH, School of Engineering Sciences (SCI), Solid Mechanics (Dept.), Biomechanics.
2010 (English)In: JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS, ISSN 1751-6161, Vol. 3, no 2, 167-177 p.Article in journal (Refereed) Published
Abstract [en]

Biomechanical data and related constitutive modelling of the mitral apparatus served as a basis for finite element analyses to better understand the physiology of mitral valves in health and disease. Human anterior and posterior leaflets and chordae tendinae from an elderly heart showing no disease and a hypertrophic obstructive cardiomyopathic heart (HOCM) were mechanically tested by means of uniaxial cyclic extension tests under quasi-static conditions. Experimental data for the leaflets and the chordae tendinae showed highly nonlinear mechanical behaviours and the leaflets were anisotropic. The mitral valve from the HOCM heart exhibited a significantly softer behaviour than the valve from the healthy one. A comparison with porcine data was included because many previous mitral modelling studies have been based on porcine data. Some differences in mechanical response were observed. Material parameters for hyperelastic, transversely isotropic constitutive laws were determined. The experimental data and the related model parameters were used in two finite element studies to investigate the effects of the material properties on the mitral valve response during systole. The analyses showed that during systole the mitral valve from the HOCM heart bulged into the left atrium by taking on the shape of a balloon, whereas the anterior leaflet of the healthy valve remained in the left ventricle.

Place, publisher, year, edition, pages
2010. Vol. 3, no 2, 167-177 p.
Keyword [en]
finite-element-analysis, chordae tendineae, closure sound, tissue, leaflet, repair, tests
National Category
Medical Laboratory and Measurements Technologies Applied Mechanics
URN: urn:nbn:se:kth:diva-19257DOI: 10.1016/j.jmbbm.2009.05.004ISI: 000274987000005ScopusID: 2-s2.0-73249151111OAI: diva2:337304
QC 20100525Available from: 2010-08-05 Created: 2010-08-05 Last updated: 2011-01-20Bibliographically approved

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Holzapfel, Gerhard A.
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Medical Laboratory and Measurements TechnologiesApplied Mechanics

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