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The C1orf9 gene encodes a putative transmembrane member of a novel protein family
KTH, Superseded Departments, Biotechnology.
KTH, Superseded Departments, Biotechnology.
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2000 (English)In: Biochemical and Biophysical Research Communications - BBRC, ISSN 0006-291X, E-ISSN 1090-2104, Vol. 267, no 3, 855-862 p.Article in journal (Refereed) Published
Abstract [en]

Here we report the characterization of a human mRNA encoding a novel protein denoted C1orf9 (chromosome 1 open reading frame 9). The cDNA sequence, derived from a testis cDNA library, contains 5700 bp which encodes an open reading frame of 1254 amino acids, The deduced protein contains a putative N-terminal signal peptide and one putative transmembrane region, indicating membrane localization. No significant homology was found with known characterized proteins. However, a 150 amino acid region has significant homology to deduced protein sequences from other organisms, including Caenorhabditis elegans (43% identity), Saccharomyces cerevisiae (47% identity), Schizosaccharomyces pombe (48% identity), and two proteins from Arabidopsis thaliana (42% and 40% identity), suggesting a novel family of conserved domains. The Clorf9 gene was assigned to chromosome 1q24. The gene spans approximately 78.7 kb and is organized into at least 24 exons. Expression analysis revealed a single Clorf9 mRNA species of approximately 6.0 kb with a predominant expression in pancreas and testis, and only low levels of expression in other tissues examined.

Place, publisher, year, edition, pages
2000. Vol. 267, no 3, 855-862 p.
Keyword [en]
polymerase chain-reaction, differential display, molecular-cloning, messenger-rnas, identification, expression, sequence, cdna, programs, system
URN: urn:nbn:se:kth:diva-19514ISI: 000085131800031OAI: diva2:338206
QC 20100525Available from: 2010-08-10 Created: 2010-08-10Bibliographically approved

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