Microwave-mediated palladium-catalyzed asymmetric allylic alkylation; an example of highly selective fast chemistry
2000 (English)In: Journal of Organometallic Chemistry, ISSN 0022-328X, E-ISSN 1872-8561, Vol. 603, no 1, 2-5 p.Article in journal (Refereed) Published
Highly enantioselective palladium-catalyzed microwave-mediated fast chemistry has been performed on dimethyl malonate alkylation of(rac)-1,3-diphenylallyl-1-acetate (1). Utilizing the recently developed palladium-phosphineoxazoline catalytic system, with general stability at elevated temperatures (less than or equal to 145 degrees C), quantitative yields of greater than or equal to 97% and ee values of up to >99% were obtained after very short irradiation times (15-300 s, TOF up to 7000 h(-1)).
Place, publisher, year, edition, pages
2000. Vol. 603, no 1, 2-5 p.
allylic alkylation, enantioselectivity, fast chemistry, microwave chemistry, palladium-catalysis, oxazoline ligands, substitution, induction
IdentifiersURN: urn:nbn:se:kth:diva-19913ISI: 000088285600002OAI: oai:DiVA.org:kth-19913DiVA: diva2:338605
QC 201005252010-08-102010-08-10Bibliographically approved