Rapid degradation of the presequence of the F-1 beta precursor of the ATP synthase inside mitochondria
2000 (English)In: Biochemical Journal, ISSN 0264-6021, E-ISSN 1470-8728, Vol. 349, 703-707 p.Article in journal (Refereed) Published
We have investigated the fate of the presequence of an overexpressed protein derived from the precursor of the F(1)beta subunit of ATP synthase after import and processing in mitochondria. Our studies revealed a rapid degradation of the presequence inside mitochondria catalysed by matrix-located protease(s). In contrast, the mature portion of the precursor was not degraded. This is the first experimental evidence of the rapid degradation of the F(1)beta a mitochondrial presequence in organello after in vitro import and processing.
Place, publisher, year, edition, pages
2000. Vol. 349, 703-707 p.
protein import, proteolysis, signal peptide, nitric-oxide synthase, protein import, processing peptidase, thimet oligopeptidase, synthetic presequence, yeast mitochondria, targeting peptides, cleavage, sequence, binding
IdentifiersURN: urn:nbn:se:kth:diva-19959ISI: 000088712000006OAI: oai:DiVA.org:kth-19959DiVA: diva2:338651
QC 201005252010-08-102010-08-10Bibliographically approved