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Preparation of chiral enantiopure 2-(hydroxyalkyl)pyridine derivatives. Use of the chiral pool
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2000 (English)In: Journal of the Chemical Society-Perkin Transactions 1, ISSN 1470-4358, no 12, 1983-1990 p.Article, review/survey (Refereed) Published
Abstract [en]

Enantiomerically pure 2-(1-hydroxyalkyl)pyridines were prepared via reaction of 2-lithiopyridine with (R)-2,3-O-isopropylideneglyceraldehyde, methyl (S)-2-methoxypropionate and methyl (S)-2-methoxy-2-phenylacetate, obtained from D-mannitol, L-lactic acid and L-mandelic acid, respectively. 6,6'-Bis(1-hydroxyalkyl)-2,2'-bipyridines were obtained from the same naturally occurring chiral compounds and 2-bromo-6-lithiopyridine with subsequent Ni-catalysed coupling.

Place, publisher, year, edition, pages
2000. no 12, 1983-1990 p.
Keyword [en]
active alpha-phenylpyridylmethanols, enantioselective conjugate addition, typical aromatic heterocycles, dynamic kinetic resolution, baylis-hillman reactions, beta-amino alcohols, bakers-yeast, asymmetric reduction, cell-cultures, catalyzed transesterifications
URN: urn:nbn:se:kth:diva-19967DOI: 10.1039/b000269kISI: 000088759600027OAI: diva2:338660
QC 20100525Available from: 2010-08-10 Created: 2010-08-10Bibliographically approved

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Moberg, Christina
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