Controlled ring-opening polymerization of lactones and lactides
2000 (English)In: Macromolecular Symposia, ISSN 1022-1360, E-ISSN 1521-3900, Vol. 157, 39-46 p.Article in journal (Refereed) Published
1,5-dioxepan-2-one (DXO) is presented as a versatile component in biodegradable polymers for biomedical applications. Copolymerization of DXO and L-lactide yielded a semi-crystalline, yet flexible, material where the extent of crystallinity and erosion characteristics were controlled by an appropriate choice of copolymer composition. Crosslinked PDXO was polymerized as a novel biodegradable elastomer. The degradation behavior of these materials were explored in vitro. Microspheres from poly(DXO-co-L-LA) were prepared and shown to be promising candidates for controlled release. The polymer composition and drug solubility provided effective means of controlling the drug delivery pattern.
Place, publisher, year, edition, pages
2000. Vol. 157, 39-46 p.
IdentifiersURN: urn:nbn:se:kth:diva-20066ISI: 000089632200006OAI: oai:DiVA.org:kth-20066DiVA: diva2:338759
QC 201005252010-08-102010-08-10Bibliographically approved