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Stability of protein-bound glycyl radical: a density functional theory study
2000 (English)In: Chemical Physics Letters, ISSN 0009-2614, E-ISSN 1873-4448, Vol. 328, no 3, 270-276 p.Article in journal (Refereed) Published
Abstract [en]

Density functional theory is used to study different models of the glycyl radical in proteins. The radical is characterized by means of the C-alpha-H bond strength, geometry, spin distribution, and hyperfine parameters. It is shown that, due to substituent effects from the peptide bond, the protein-bound glycyl radical is less stable than the nonprotein-bound one. This effect is of great importance for the biological function of the glycyl radical. The capto-dative resonance stabilization is confirmed, and new resonances are suggested to arise due to the peptide bond, resulting in further delocalization of the unpaired spin.

Place, publisher, year, edition, pages
2000. Vol. 328, no 3, 270-276 p.
Keyword [en]
pyruvate formate-lyase, anaerobic ribonucleotide reductase, exchange, energy, site
URN: urn:nbn:se:kth:diva-20088ISI: 000089775800005OAI: diva2:338781
QC 20100525Available from: 2010-08-10 Created: 2010-08-10Bibliographically approved

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Himo, Fahmi
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