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Staphylococcal surface display and its applications
KTH, Superseded Departments (pre-2005), Biotechnology.
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2000 (English)In: International Journal of Medical Microbiology, ISSN 1438-4221, E-ISSN 1618-0607, Vol. 290, no 7, p. 571-577Article, review/survey (Refereed) Published
Abstract [en]

Novel surface proteins can be introduced onto the bacterial cell surface by recombinant means. Here, we describe the development of such display systems for two food-grade bacteria, Staphylococcus carnosus and Staphylococcus xylosus, and present how such engineered bacteria can be used in different applications. A study will be described in which such staphylococci were employed as vaccine delivery vehicles to elicit protective antibody responses to respiratory syncytial virus (RSV). The use of surface-engineered staphylococci as novel microbial biocatalysts, as a new type of whole-cell diagnostic devices or for adsorption of metal ions with potential environmental or biosensor applications, will also be discussed.

Place, publisher, year, edition, pages
2000. Vol. 290, no 7, p. 571-577
Keywords [en]
Staphylococcus carnosus, Staphylococcus xylosus, vaccine delivery, diagnostic tools, environmental applications, toxin-b subunit, cell-surface, combinatorial libraries, recombinant proteins, antibody-responses, vaccine delivery, binding, carnosus, xylosus, aureus
Identifiers
URN: urn:nbn:se:kth:diva-20313DOI: 10.1016/s1438-4221(00)80002-8ISI: 000166589000002PubMedID: 11200538Scopus ID: 2-s2.0-0034510870OAI: oai:DiVA.org:kth-20313DiVA, id: diva2:339007
Note
QC 20100525Available from: 2010-08-10 Created: 2010-08-10 Last updated: 2022-06-25Bibliographically approved

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Citation style
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  • de-DE
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  • nn-NB
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  • Other locale
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Output format
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