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Staphylococcal surface display and its applications
KTH, Superseded Departments, Biotechnology.
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2000 (English)In: International Journal of Medical Microbiology, ISSN 1438-4221, E-ISSN 1618-0607, Vol. 290, no 7, 571-577 p.Article, review/survey (Refereed) Published
Abstract [en]

Novel surface proteins can be introduced onto the bacterial cell surface by recombinant means. Here, we describe the development of such display systems for two food-grade bacteria, Staphylococcus carnosus and Staphylococcus xylosus, and present how such engineered bacteria can be used in different applications. A study will be described in which such staphylococci were employed as vaccine delivery vehicles to elicit protective antibody responses to respiratory syncytial virus (RSV). The use of surface-engineered staphylococci as novel microbial biocatalysts, as a new type of whole-cell diagnostic devices or for adsorption of metal ions with potential environmental or biosensor applications, will also be discussed.

Place, publisher, year, edition, pages
2000. Vol. 290, no 7, 571-577 p.
Keyword [en]
Staphylococcus carnosus, Staphylococcus xylosus, vaccine delivery, diagnostic tools, environmental applications, toxin-b subunit, cell-surface, combinatorial libraries, recombinant proteins, antibody-responses, vaccine delivery, binding, carnosus, xylosus, aureus
URN: urn:nbn:se:kth:diva-20313ISI: 000166589000002OAI: diva2:339007
QC 20100525Available from: 2010-08-10 Created: 2010-08-10Bibliographically approved

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