Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
The role of protein kinase C in the biochemical pathways of classical conditioning
2001 (English)In: Neurocomputing, ISSN 0925-2312, E-ISSN 1872-8286, Vol. 38, 79-85 p.Article in journal (Refereed) Published
Abstract [en]

Evidence suggests that protein kinase C (PKC) is required for long term memory storage such as classical conditioning. Stimulation of parallel fibers (PF) and climbing fibers (CF) of the cerebellum leads to production of the second messengers diacylglycerol, arachidonic acid, and calcium which are activators of PKC. A model is developed that describes the cascade of biochemical reactions in response to PF and CF stimulation and leading to PKC activation. Model simulations are used to evaluate the temporal specificity of PKC activation and the sensitivity of PKC activation to the interstimulus interval (ISI) of classical conditioning. Simulations at different ISI show that if PF stimulation precedes CF stimulation, PKC activation is elevated.

Place, publisher, year, edition, pages
2001. Vol. 38, 79-85 p.
Keyword [en]
protein kinase C (PKC) activation, classical conditioning, arachidonic acid (AA), diacylglycerol (DAG), long-term depression, cerebellar purkinje-cell, active membrane model, arachidonic-acid, simulation, slice, pkc
Identifiers
URN: urn:nbn:se:kth:diva-20686ISI: 000169129200012OAI: oai:DiVA.org:kth-20686DiVA: diva2:339382
Note
QC 20100525Available from: 2010-08-10 Created: 2010-08-10 Last updated: 2017-12-12Bibliographically approved

Open Access in DiVA

No full text

Authority records BETA

Hellgren Kotaleski, Jeanette

Search in DiVA

By author/editor
Hellgren Kotaleski, Jeanette
In the same journal
Neurocomputing

Search outside of DiVA

GoogleGoogle Scholar

urn-nbn

Altmetric score

urn-nbn
Total: 70 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf