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Entorhinal neuronal activity during delayed matching tasks may depend upon muscarinic-induced non-specific cation current I(CANM)
KTH, Superseded Departments, Numerical Analysis and Computer Science, NADA.ORCID iD: 0000-0003-0281-9450
2001 (English)In: Neurocomputing, ISSN 0925-2312, Vol. 38, 601-606 p.Article in journal (Refereed) Published
Abstract [en]

Biophysical compartmental models of stellate, pyramidal-like and interneurons in layer II of the rat entorhinal cortex were used to explore cellular and synaptic components involved in neuronal responses to stimuli in a delayed match to sample (DMS) task. Simulations demonstrate that the muscarinic receptor-induced non-specific cation current, I(CANM), could contribute to these phenomena. Facilitation of I(CANM) by calcium influx during spikes induced by the sample stimulus can cause enhanced responses for matches as well as delay activity. In a network, lateral inhibition can produce match suppression, and in conjunction with stimulus selective/non-selective cells produce non-match enhancement and suppression.

Place, publisher, year, edition, pages
2001. Vol. 38, 601-606 p.
Keyword [en]
biophysical simulation, entorhinal cortex, working memory, cortex layer-ii
National Category
Neurosciences Bioinformatics (Computational Biology)
URN: urn:nbn:se:kth:diva-20689ISI: 000169129200080OAI: diva2:339385
QC 20100525Available from: 2010-08-10 Created: 2010-08-10 Last updated: 2011-12-14Bibliographically approved

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Fransén, Erik
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