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Evaluation of using absolute versus relative base level when analyzing brain activation images using the scale-space primal sketch
KTH, School of Computer Science and Communication (CSC), Computational Biology, CB.ORCID iD: 0000-0002-9081-2170
2001 (English)In: Medical Image Analysis, ISSN 1361-8415, E-ISSN 1361-8423, Vol. 5, no 2, 89-110 p.Article in journal (Refereed) Published
Abstract [en]

A dominant approach to brain mapping is to define functional regions in the brain by analyzing images of brain activation obtained from positron emission tomography (PET) and functional magnetic resonance imaging (fMRI). This paper presents an evaluation of using one such tool, called the scale-space primal sketch, for brain activation analysis. A comparison is made concerning two possible definitions of a significance measure of blob structures in scale-space, where local contrast is measured either relative to a local or global reference level. Experiments on real brain data show that (i) the global approach with absolute base level has a higher degree of correspondence to a traditional statistical method than a local approach with relative base level, and that (ii) the global approach with absolute base level gives a higher significance to small blobs that are superimposed on larger scale structures, whereas the significance of isolated blobs largely remains unaffected. Relative to previously reported works, the following two technical improvements are also presented. (i) A post-processing tool is introduced for merging blobs that are multiple responses to image structures. This simplifies automated analysis from the scale-space primal sketch. (ii) A new approach is introduced for scale-space normalization of the significance measure, by collecting reference statistics of residual noise images obtained from the general Linear model.

Place, publisher, year, edition, pages
2001. Vol. 5, no 2, 89-110 p.
Keyword [en]
brain activation, brain mapping, functional region, scale-space, primal sketch, cerebral activation, clusters, tactile
National Category
Computer Science Bioinformatics (Computational Biology) Computer Vision and Robotics (Autonomous Systems) Neurosciences
URN: urn:nbn:se:kth:diva-20756DOI: 10.1016/S1361-8415(00)00037-2ISI: 000169672400002PubMedID: 11516705OAI: diva2:339453

QC 20100525

Available from: 2013-04-22 Created: 2010-08-10 Last updated: 2013-04-22Bibliographically approved

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