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Choosing priority-setting criteria for carcinogens
KTH, Superseded Departments, History of Science and Technology.
2001 (English)In: Human and Ecological Risk Assessment, ISSN 1080-7039, Vol. 7, no 3, 475-491 p.Article in journal (Refereed) Published
Abstract [en]

For priority-setting purposes, simple criteria are needed to estimate, provisionally, the inherent properties of potential carcinogens for which adequate data are not available. Expected utility analysis is used to evaluate three such criteria from a decision-theoretic point of view: (1) the species criterion, which assigns lower priority to experimental than to epidemiological carcinogens, (2) the genotoxicity criterion, which prioritizes substances known to be genotoxic, and (3) the potency criterion, which apportions priorities according to carcinogenic potencies that are derived from animal experiments. The outcome of this analysis is favorable to the potency criterion. It is concluded that considerations of potency should have a much more prominent role than what they have in current regulatory practice.

Place, publisher, year, edition, pages
2001. Vol. 7, no 3, 475-491 p.
Keyword [en]
carcinogen regulation, regulation, decision theory, priority-setting, carcinogenic potency, TD50, bioassay data, potency, risk, chemicals, humans, animals, cancer, classification, extrapolation, mutagenicity
URN: urn:nbn:se:kth:diva-20769ISI: 000169751100002OAI: diva2:339466
QC 20100525Available from: 2010-08-10 Created: 2010-08-10Bibliographically approved

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