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An introduction to DNA chips: principles, technology, applications and analysis
KTH, Superseded Departments, Biotechnology.
2001 (English)In: Acta Biochimica Polonica, ISSN 0001-527X, Vol. 48, no 3, 615-622 p.Article, review/survey (Refereed) Published
Abstract [en]

This review describes the recently developed GeneChip technology that provides efficient access to genetic information using miniaturised, high-density arrays of DNA or oligonucleotide probes. Such microarrays are powerful tools to study the molecular basis of interactions on a scale that would lie impossible using conventional analysis. The recent development of the microarray technology has greatly accelerated the investigation of gene regulation. Arrays are mostly used to identify which genes are turned on or off in a cell or tissue, and also, to evaluate the extent of a gene's expression under various conditions. Indeed, this technology has been successfully applied to investigate simultaneous expression of many thousands of genes and to the detection of mutations or polymorphisms, as well as for their mapping and sequencing.

Place, publisher, year, edition, pages
2001. Vol. 48, no 3, 615-622 p.
Keyword [en]
oligonucleotide array, DNA array, gene expression, hybridisation, oligonucleotide arrays, human genome, escherichia-coli, nucleic-acids, large-scale, hybridization, microarrays
URN: urn:nbn:se:kth:diva-20980ISI: 000171292600004OAI: diva2:339677
QC 20100525Available from: 2010-08-10 Created: 2010-08-10Bibliographically approved

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