Tailored mechanical properties and degradability of polyesters by controlled molecular architecture
2001 (English)In: Macromolecular Symposia, ISSN 1022-1360, E-ISSN 1521-3900, Vol. 175, 11-18 p.Article in journal (Refereed) Published
Advanced molecular architectures have been used as a toot for tailoring the mechanical properties and the degradation process of polymers for specific applications. Crosslinked poly(1,5-dioxepan-2-one), random poly(1,5-dioxepan-2-one-co-L-lactide), triblock poly(L-lactide-b-1,5-dioxepan-2-one-b-L-lactide) and triblock poly(epsilon -caprolactone-b-1,5-dioxepan-2-one-b-epsilon -caprolactone) have been synthesized and their thermal and mechanical properties as well as degradation times and degradation products have been characterized and compared. The stress at break of the synthesized polymers ranged from 4 MPa to 55 MPa and the elongation at break from 25% to 1200%. The degradation time varied from 70 days up to 360 days. These polymers are suitable as films or microspheres for controlled drug delivery or as temporary tissue replacements e.g. for tendons or nerve guides.
Place, publisher, year, edition, pages
2001. Vol. 175, 11-18 p.
ring-opening polymerization, epsilon-caprolactone, l-lactide, macrocyclic polymerization, hydrolytic degradation, l-dilactide, 1,5-dioxepan-2-one, copolymers, behavior, d,l-dilactide
IdentifiersURN: urn:nbn:se:kth:diva-21086ISI: 000172082700003OAI: oai:DiVA.org:kth-21086DiVA: diva2:339783
QC 201005252010-08-102010-08-10Bibliographically approved