Change search
ReferencesLink to record
Permanent link

Direct link
Volume kinetics of glucose solutions given by intravenous infusion
KTH, Superseded Departments, Numerical Analysis and Computer Science, NADA.
2001 (English)In: British Journal of Anaesthesia, ISSN 0007-0912, E-ISSN 1471-6771, Vol. 87, no 6, 834-843 p.Article in journal (Refereed) Published
Abstract [en]

Glucose solutions given by intravenous (i.v.) infusion exert volume effects that are governed by the amount of fluid administered and also by the metabolism of the glucose. To understand better how the body handles glucose solutions, two volume kinetic models were developed in which consideration was given to the osmotic fluid shifts that accompany the metabolism of glucose. These models were fitted to data obtained when 21 volunteers who were given approximately 1 litre of glucose 2.5 or 5% or Ringer's solution (control) over 45 min. The maximum haemodilution was similar for all three fluids, but it decreased more rapidly when glucose had been infused. The volume of distribution for the infused glucose molecules was larger (similar to 12 litres) than for the infused fluid, which amounted to (mean (SEM)) 3.7 (0.3) (glucose 2.5%). 2.8 (0.2) (glucose 5%), and 2.5 (0.2) litres (Ringer). Fluid accumulated in a remote (cellular) body fluid space when glucose had been administered (similar to0.2 and 0.4 litres, respectively), while expansion of an intermediate fluid space (7.1 (13) litres) could be demonstrated in 33% of the Ringer experiments. In conclusion, kinetic models were developed which consider the relationship between the glucose metabolism and the disposition of intravenous fluid. One of them, in which infused fluid expands two instead of three body fluid spaces, was successfully fitted to data on blood glucose and blood haemoglobin obtained during infusions of 2.5 and 5% glucose.

Place, publisher, year, edition, pages
2001. Vol. 87, no 6, 834-843 p.
Keyword [en]
fluids, i.v., blood, haemodilution, pharmacokinetics, metabolism, , glucose, blood, haemoglobin, ringers solution, volunteers, fluid, sheep
URN: urn:nbn:se:kth:diva-21161ISI: 000172627100006OAI: diva2:339858

QC 20100525

Available from: 2010-08-10 Created: 2010-08-10 Last updated: 2014-09-24Bibliographically approved

Open Access in DiVA

No full text

Search in DiVA

By author/editor
Edsberg, Lennart
By organisation
Numerical Analysis and Computer Science, NADA
In the same journal
British Journal of Anaesthesia

Search outside of DiVA

GoogleGoogle Scholar
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Total: 18 hits
ReferencesLink to record
Permanent link

Direct link