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Microwave-mediated ruthenium-catalyzed asymmetric hydrogen transfer
KTH, Superseded Departments, Chemistry.ORCID iD: 0000-0002-1743-7650
2001 (English)In: Tetrahedron: asymmetry, ISSN 0957-4166, E-ISSN 1362-511X, Vol. 12, no 18, 2529-2532 p.Article in journal (Refereed) Published
Abstract [en]

Ru-catalyzed hydrogen transfer from propan-2-ol to acetophenone under microwave conditions using monotosylated (R,R)-diphenylethylenediamine as the chiral source afforded (R)-1-phenylethanol in >90% yield and 82% e.e. within 9 min, while use of ephedrine or norephedrine gave the same compound in high yield with 70 and 46% e.e., respectively. t-Butylphenylketone was reduced to (R)-2,2-dimethyl-1-phenyl-1-propanoI under the same conditions in close to quantitative yield, although with low enantioselectivity.

Place, publisher, year, edition, pages
2001. Vol. 12, no 18, 2529-2532 p.
Keyword [en]
allylic alkylation, carbonyl-compounds, aromatic ketones, fast chemistry, ligands, efficient, complexes, reduction, alcohols, example
URN: urn:nbn:se:kth:diva-21162ISI: 000172642400006OAI: diva2:339859
QC 20100525Available from: 2010-08-10 Created: 2010-08-10Bibliographically approved

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