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Interpretations of primary carcinogenicity data in 29 trichloroethylene risk assessments
2001 (English)In: Toxicology, ISSN 0300-483X, E-ISSN 1879-3185, Vol. 169, no 3, 209-225 p.Article in journal (Refereed) Published
Abstract [en]

This paper explores to what extent interpretations of individual primary carcinogenicity data differ between different risk assessors, and discusses possible reasons for such differences as well as their impact on the overall risk assessment conclusions. For this purpose 29 different TCE carcinogenicity risk assessments are used as examples. It is concluded that the TCE risk assessors surprisingly often interpret and evaluate primary data differently. Two particular reasons for differences in data interpretation are discussed: different assessments of statistics, and different assessments of whether the results obtained in bioassays have toxicological relevance. Differences in the interpretation and evaluation of epidemiological data are also explored and discussed.

Place, publisher, year, edition, pages
2001. Vol. 169, no 3, 209-225 p.
Keyword [en]
primary carcinogenicity data, trichloroethylene, risk assessments, regulatory toxicology, cohort, cancer, workers, exposure, hydrocarbons, mortality, mice
Identifiers
URN: urn:nbn:se:kth:diva-21222ISI: 000173055600005OAI: oai:DiVA.org:kth-21222DiVA: diva2:339919
Note
QC 20100525Available from: 2010-08-10 Created: 2010-08-10 Last updated: 2017-12-12Bibliographically approved

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