Epigenetics as a first exit problem
2002 (English)In: Physical Review Letters, ISSN 0031-9007, Vol. 88, no 4Article in journal (Refereed) Published
We develop a framework to discuss the stability of epigenetic states as first exit problems in dynamical systems with noise. We consider in particular the stability of the lysogenic state of the A prophage. The formalism defines a quantitative measure of robustness of inherited states.
Place, publisher, year, edition, pages
2002. Vol. 88, no 4
bacteriophage-lambda, escherichia-coli, translation initiation, cro, transcription, repressor, robustness, switch, site
IdentifiersURN: urn:nbn:se:kth:diva-21326DOI: 10.1103/PhysRevLett.88.048101ISI: 000173907500081OAI: oai:DiVA.org:kth-21326DiVA: diva2:340024
QC 201005252010-08-102010-08-10Bibliographically approved