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Epigenetics as a first exit problem
KTH, Superseded Departments, Numerical Analysis and Computer Science, NADA.
2002 (English)In: Physical Review Letters, ISSN 0031-9007, Vol. 88, no 4Article in journal (Refereed) Published
Abstract [en]

We develop a framework to discuss the stability of epigenetic states as first exit problems in dynamical systems with noise. We consider in particular the stability of the lysogenic state of the A prophage. The formalism defines a quantitative measure of robustness of inherited states.

Place, publisher, year, edition, pages
2002. Vol. 88, no 4
Keyword [en]
bacteriophage-lambda, escherichia-coli, translation initiation, cro, transcription, repressor, robustness, switch, site
URN: urn:nbn:se:kth:diva-21326DOI: 10.1103/PhysRevLett.88.048101ISI: 000173907500081OAI: diva2:340024
QC 20100525Available from: 2010-08-10 Created: 2010-08-10Bibliographically approved

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Aurell, Erik
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