Change search
ReferencesLink to record
Permanent link

Direct link
Tumor localization and image registration of F-18FDG coincidence detection scans with computed tomographic scans
Show others and affiliations
2002 (English)In: Clinical Nuclear Medicine, ISSN 0363-9762, E-ISSN 1536-0229, Vol. 27, no 4, 275-282 p.Article in journal (Refereed) Published
Abstract [en]

Purpose: The aim of this study was to determine the feasibility of registering routine clinical F-18 fluorodeoxyglucose (FDG) coincidence detection (CD) scans with computed tomographic (CT) scans for radiation treatment planning and case management. Methods: F-18 FDG CD and chest CT scans, performed in 10 randomly selected patients with confirmed or possible adenocarcinoma of the lung, were evaluated. The quality of the matches was verified by comparisons of the center-to-center distance between a region of interest (ROI) manually drawn on the CT slice and warped onto the CD slice with an ROI drawn manually directly on the CD slice. In addition, the overlap between the two ROIs was calculated. Results: All 10 F-18 FDG CD and CT scans were registered with good superimposition of soft tissue density on increased radionuclide activity. The center-to-center distance between the ROIs ranged from 0.29 mm to 8.08 mm, with an average center-to-center distance of 3.89 mm 2.42 mm (0.69 pixels +/- 0.34 pixels). The ROI overlap ranged from 77% to 99%, with an average of 90% +/- 5.6%. Conclusions: Although the use of F-18 FDG CD shows great promise for the identification of tumors, it shares the same drawbacks as those associated with radiolabeled monoclonal antibody SPECT and ligand-based positron emission tomographic scans in that anatomic markers are limited. This study shows that image registration is feasible and may improve the clinical relevance of CD images.

Place, publisher, year, edition, pages
2002. Vol. 27, no 4, 275-282 p.
Keyword [en]
case management, coincidence detection, computed tomography, feasibility of image registration, fluorodeoxyglucose, intermodality image registration, lung carcinoma, cell lung-cancer, positron emission tomography, solitary pulmonary nodules, ct-spect fusion, monoclonal-antibody, gamma-camera, fdg spect, pet, carcinoma, 2--fluoro-2-deoxy-d-glucose
National Category
Radiology, Nuclear Medicine and Medical Imaging
Research subject
URN: urn:nbn:se:kth:diva-21397DOI: 10.1097/00003072-200204000-00008ISI: 000174511100008PubMedID: 11914668OAI: diva2:340095
QC 20100525 QC 20111115 Available from: 2010-08-10 Created: 2010-08-10 Last updated: 2013-09-09Bibliographically approved

Open Access in DiVA

No full text

Other links

Publisher's full textPubMed

Search in DiVA

By author/editor
Maguire, Gerald Q. Jr.
By organisation
Microelectronics and Information Technology, IMIT
In the same journal
Clinical Nuclear Medicine
Radiology, Nuclear Medicine and Medical Imaging

Search outside of DiVA

GoogleGoogle Scholar
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 215 hits
ReferencesLink to record
Permanent link

Direct link